Summer Internship: Real-time dose/response analysis of syngeneic mouse data in discovery

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Job Description

The DMPK&M oncology modeling group develops mechanistic mathematical models of drug candidates and their effects on cancer using in vitro and animal data in order to translate preclinical findings into clinical projections of target patient population, biomarker modulation, and dose-response relationships. We partner closely with bench scientists and clinicians to provide high-quality decision support to early drug R&D

Job Description:

Takeda Oncology Drug Discovery Unit (ODDU) screens immuno-oncology (IO) lead molecules (leads) by testing them in syngeneic mouse models. One DMPK&M role is to assess the data from these mouse models to rank-order these leads, to estimate dose-response relationship, and to help choose doses for future studies. Our mathematical modelers have various bespoke approaches to these predictions, and this process can be inconsistent and time-consuming.

This summer internship project seeks to address these issues by setting up a semi-automated user-friendly tumor assessment system that considers humane censoring and individual mouse tumor volume trajectories to produce a quick, consistent and unbiased estimate of the effect of Takeda discovery lead molecules on tumor growth dynamics.

The intern will

• Speed up and increase quality of determining the dose-response relationship for potency of drug candidates

• Provide the accurate comparison among leads and to reference compound

• Provide companywide practices to relieve ODDU and DMPK&M scientists from high-workload data manipulations and calculations.

Internship Development Opportunities:

• Exposure to PK/PD and tumor dynamic modeling in an industrial setting

• Learn to understand different ways of working in the oncology modeling field

• Experience with gathering requirements and 'customer' (ie Project Representative) management

Job Requirements:

• This position will be Hybrid and require 2-3 days in the Cambridge, MA office per week.

• Must be a PhD candidate in Applied Mathematics, Biomedical/Chemical Engineering, or Pharmaceutics

• Must have prior exposure to ODE modeling of biological processes, web-based application (e.g. R-shiny) development, and programmatic wrangling of sub-optimally formatted data sets.

• Highly reliable and a strong team player

• Flexible with an attention to detail

• Strong verbal and written communication skills

Internship Eligibility

• Must be authorized to work in the U.S. on a permanent basis without requiring sponsorship

• Must be currently enrolled in a degree program graduating December 2025 or later

• The internship program is 10-12 weeks depending on the two start dates (June 2nd- August 29th) or (June 16th - August 22nd)

• The intern must be able to commit to one of these time frames

• Able to work full time 40 hours a week during internship dates

• Takeda does not provide a housing stipend or relocation support for the U.S Summer Internship Program

Program Highlights:

• Hands-on experience with real projects and responsibilities

• Dedicated mentorship program pairing interns with experienced professionals

• Networking opportunities with industry professionals and fellow interns

• Internship events focused on professional and skills development

• Exposure to multiple business areas or departments within a Pharmaceutical Organization

Applications will be accepted between January 6th and January 31st

Takeda Compensation and Benefits Summary

We understand compensation may be an important factor as you consider an internship opportunity. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Hourly Wage Range:

$21.00 - $46.00

The estimated hourly range reflects an anticipated range for this position. The actual hourly wage offered will depend on the candidate's school year/level to be entered following completion of internship. The actual hourly wage offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. internship benefits vary by location and may include:

• Paid sick time

• Civic Duty paid time off

• Participation at company volunteer events

• Participation at company sponsored special events

• Access to on-site fitness center (where available)

• Commuter Benefit: To offset your work-commute expenses, Takeda provides U.S. employees with a fixed monthly subsidy to be used for either public transportation (transit) or parking.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Paid Intern (Fixed Term) (Trainee)

Time Type

Full time

Job Exempt

No