Senior Scientist, ADC Chemistry

Senior Scientist - Pfizer Oncology, ADC chemistry Bothell, WA

ROLE SUMMARY

We are looking for a highly motivated and collaborative researcher to join our ADC chemistry team in a lab-based role to support novel Antibody Drug Conjugate (ADC) discovery research and development. The successful candidate will develop analytical and purification solutions to support a synthetic chemistry team, with a particular focus on applying HPLC-MS and preparative HPLC approaches to characterize and purify complex drug-linkers.

ROLE RESPONSIBILITIES

• Maintain, calibrate, and troubleshoot a suite of open-access UPLC/MS and preparatory HPLC systems in an early-stage discovery chemistry laboratory.

• Coordinate with internal lab operations and service engineers when necessary (e.g., significant hardware repairs, annual preventative maintenance).

• Operate a variety of chromatography instruments and provide subject matter expertise to enable purity assessment and concentration validation of complex synthetic molecules, as well as develop fit for purpose walk-up methods to assess drug-linker reactivity.

• Optimize workflows that accelerate open access preparative-scale HPLC purification of synthetic intermediates and final compounds.

• Collaborate with the synthetic chemistry team to develop custom-tailored approaches for challenging separations.

• Ensure data is readily available to end-users and properly archived through cross-functional coordination with IT and data management teams.

• Interact with partners in development roles (e.g., process chemistry, GxP functions) to align strategies and ensure efficient data transfer as projects progress to IND-enabling studies.

• Actively participate in training colleagues on the proper use of new equipment and technologies.

• Adhere to all company safety, scientific record keeping, and compliance requirements.

BASIC QUALIFICATIONS:

• Bachelor's degree and 9+ years experience; Master's Degree and 7+ years of experience; or PhD and 0-3 years experience

• Experience working in a small molecule purifications group, preferably in collaboration with a discovery and/or lead optimization chemistry team.

• Extensive experience in maintaining UPLC-MS and preparative HPLC instrumentation and deployment of fit-for-purpose work flows.

• Demonstrated ability to work effectively in multi-disciplinary teams, learn new skills and proactively identify and address analytical challenges.

• Experience developing new analytical LC-MS methods for walk-up applications.

• Strong interpersonal skills and effective written/verbal communication.

• Enthusiasm to work within a team-oriented environment with accelerated timelines

PREFERRED QUALIFICATIONS:

• Experience identifying and implementing new technologies that facilitate analysis and purification of small molecules.

• Familiarity with Waters software, as well as preparatory and analytical UPLC systems and mass spectrometers.

• Experience maintaining and utilizing mass-directed preparative HPLC.

• Experience working with antibody analytics and/or quantitative bioanalytical analysis via HPLC-MS/MS.

• Experience with automation of parallel sample management and data processing, including basic programming skills

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (~~~). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development