2025 U.S Summer Internship Program: In-Vitro ADME Assessment using Organ-on-Chip Intern

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Job Description

Takeda has been translating science into breakthrough medicines for 240 years. Every step of the way, our teams have worked together to tackle some of the most challenging problems in drug discovery and development. Today, we're a driving force behind innovative therapies that make a lasting difference to millions of patients around the world.

In R&D, all of our history and potential comes together in an environment that welcomes diversity of thought and amplifies every voice. Working closely with colleagues, you'll play a key role in bringing our rich pipeline of products forward to help patients. Come join a team that's earned trust for more than two centuries, and find out how advancing transformative therapies at Takeda will shape your bright future.

Job Description:

The aim of the Takeda-Boston Absorption,Distribution, Metabolism and Excretion (ADME) group is provide the intern a well-rounded in-vitro ADME and MPS/Organ-on-chip introduction by the ADME team sub-divisions.

How You Will Contribute:

The intern can expect to learn the following skill sets during their rotation in the Biodistribution and Mechanistic ADME groups:

• Assist in the culture and maintenance of cells within MPS platforms.

• Collaborate with team members to integrate various biomolecular techniques.

• Analyze data to track the biodistribution and pharmacokinetics of therapeutic agents and other substances.

• Assess the hepatic stability profile of low, medium, and high stability compounds which require long term culture conditions.

• Assess metabolism, transcellular permeability, transport and biliary efflux in a hepatic model.

• Assess metabolism, transcellular permeability and transport in an intestinal model.

• Employ RT-qPCR to quantify gene expression levels within cultured cells.

• Utilize confocal microscopy for visualizing spatial distribution of fluorescently labeled antibodies and probes.

• Conduct ELISAs to measure the concentration of specific proteins or other molecules in the MPS.

• Contribute to the preparation of reports and presentations summarizing research findings.

Internship Development Opportunities:

The intern will gain experience and knowledge in MPS system while helping to assess the ease of use and usefulness of MPS system with specific focus areas such as transport/permeability, short and long term enzymology, biodistribution, and molecular biology.

Job Requirements:

• This position will be Fully Onsite and require 4+days in the Cambridge office per week.

• Must be a Graduate Student pursuing a Masters or Ph.D. with cell culture and molecular biology experience intersted in drug metabolism and pharmacokinetics

• Basic understanding of computer skills including MS Office (PowerPoint, Words, Excel)

• Internet skills including use of e-mails, group messaging and information gathering

• Highly reliable and a strong team player

• Flexible with an attention to detail

• Strong verbal and written communication skills

Internship Eligibility

• Must be authorized to work in the U.S. on a permanent basis without requiring sponsorship

• Must be currently enrolled in a degree program graduating December 2025 or later

• The internship program is 10-12 weeks depending on the two start dates(June 2nd- August 22nd)or(June 16th -August 29th)

• The intern must be able to commit to one of these time frames

• Able to work full time 40 hours a week during internship dates

• Takeda does not provide a housing stipend or relocation support for the U.S Summer Internship Program

Program Highlights:

• Hands-on experience with real projects and responsibilities

• Dedicated mentorship program pairing interns with experienced professionals

• Networking opportunities with industry professionals and fellow interns

• Internship events focused on professional and skills development

• Exposure to multiple business areas or departments within a Pharmaceutical Organization

Applications will be accepted between December 18th and January 10th

Takeda Compensation and Benefits Summary

We understand compensation may be an important factor as you consider an internship opportunity. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Hourly Wage Range:

$21.00 - $46.00

The estimated hourly range reflects an anticipated range for this position. The actual hourly wage offered will depend on the candidate's school year/level to be entered following completion of internship. The actual hourly wage offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. internship benefits vary by location and may include:

• Paid sick time

• Civic Duty paid time off

• Participation at company volunteer events

• Participation at company sponsored special events

• Access to on-site fitness center (where available)

• Commuter Benefit: To offset your work-commute expenses, Takeda provides U.S. employees with a fixed monthly subsidy to be used for either public transportation (transit) or parking.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Paid Intern (Fixed Term) (Trainee)

Time Type

Full time

Job Exempt

No